I briefly talked about this in the SynthV Wiki discord (so I might repeat some of the things I said there), but here are my two cents:
The news are unfortunate, but sadly, not too surprising. I generally dislike being "I told you so" at people, but tbh I kinda thought the MEDIUM 2050 game was a bad idea, especially once they unveiled that it was gonna be a mobage. Like, even before the pandemic threw a monkey wrench in the economy this seemed like something too ambitious for Quad's resources. Even with the backing they had, they were not a big comapny, nor do their character's have the monumental cultural presence and larger than life marketing that say, Crypton has. Combine that with the saturated as hell nature of the mobage scene (especially in China), the best case scenario for MEDIUM 2050 would have been a lukewarm launch, a small but dedicated fanbase of Chinese vsynth fans with preexisting investment in the IP, maybe some brave foreign players with a VPN, and then shutting down before the game's first anniversary, because the market for sci-fi mobage with anime girls is more saturated than the market for isekai light novels.
Now this combined with the preexisting issues with the company above (some of which I admit have not heard of until now) AND the pandemic, the writing was kind off on the wall. From what I heard they broke with their previous company that licenced Stardust V4 was because they felt to restricted by them, but seeing how everything turned out, maybe they needed that hands-on aproach after all.
It is kind of a shame things turned out like this thought, as much as the game did not terribly intrest me (it felt like "the honkai impact at home" so to speak to me) some of the concept art looked cool. And we did get Minus out of it, who ended up becoming my favorite Quad voice. I am paticularly saddened by the possibility of no more albums, if there is anything Quadimension is undisputably great at is music, so that is a huge loss.
Edit because I realized I had one more thing I wanted to say but didn't wanna double post: Others in the tread bringing up their protectiveness of the IP suddenly reminded me of that Symphoneme thing a while back, that online vsynth that also had infamously restrictive usage licence for the characters (in fairness to Quad, their's does not seem quite as bad, but that's a lowbar to jump when your competition is Symphoneme) as one of the reasons kneecapping it's potential success, among other things. (Thought at least Quadimension had the good sense to hire someone else actually competent to make the voicebanks and not release what could be charitably described as an unfinished alpha for their official public demo pardon the shade but I am still baffled by that)